2. Signaling Pathways
  3. Neuronal Signaling
  4. Serotonin Transporter
  5. Serotonin Transporter Ligand

Serotonin Transporter Ligand

Serotonin Transporter Ligands (2):

Cat. No. Product Name Effect Purity
  • HY-181878
    Z8779877149
    		Ligand
    Z8779877149 (Z7149) is a blood-brain barrier-permeable multi-target ligand that targets SERT (Ki=198 nM), α2A adrenergic receptor (Ki=180 nM; EC50=440 nM) and 5-HT2A receptor (EC50=172 nM, Emax=76%). Z8779877149 inhibits 5-HT reuptake and activates Gi and Gq protein signaling pathways, respectively. Z8779877149 effectively alleviates pain responses as well as depression- and anxiety-like behaviors, while exhibiting favorable safety without inducing sedation or motor impairment. Z8779877149 is available for the research of pain, depression and anxiety disorders.
  • HY-W792458
    MADAM
    		Ligand
    MADAM exhibits high affinity and selectivity for 5-HTT with a Ki value of 1.6 nM. MADAM has the potential to serve as a PET radiotracer for visualizing the serotonin transporter.